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Excedrin Migraine is an over-the-counter medication used to treat migraines. It combines three active ingredients: acetaminophen (a pain reliever), aspirin (an anti-inflammatory), and caffeine (a stimulant that enhances the effectiveness of pain relievers). These ingredients work together to reduce headache pain, inflammation, and enhance the absorption of the other medications. Excedrin Migraine is typically used to relieve the symptoms of migraines, such as throbbing headaches, nausea, and sensitivity to light and sound. It’s important to follow the recommended dosage to avoid potential side effects, especially with prolonged or excessive use.