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Natureplex Hydrocortisone is an over-the-counter topical cream that contains hydrocortisone, a mild corticosteroid used to relieve itching, redness, and inflammation caused by various skin conditions. It's commonly used to treat conditions such as insect bites, poison ivy, eczema, rashes, and allergic reactions. The hydrocortisone works by reducing the immune system’s response to the irritant, helping to soothe and calm irritated skin.